Understanding membrane protein oligomerization

Membrane protein oligomerization is critical in a myriad of biological systems. What are the rules that determine the specificity and the stability of complexes of transmembrane helices? And how does the structure of these domains support to the proteins’ function?

Our group uses biophysical and computational methods to answer these fundamental questions.

Understanding and predicting GxxxG-mediated dimerization

We are interested in understanding how stability and specificity is encoded in the sequence of the widespread GASright dimerization motif, using a combination of biophysical and computational methods.

Structure and function of membrane proteins of the bacterial divisome

The structure and mechanisms that govern bacterial cell division are still poorly understood. We use a multidisciplinary approach to shed light on this important process.