Understanding the biophysical basis of GxxxG-mediated dimerization

GASright is a common dimerization motif mediated by GxxxG

GASright is one of the most common (if not the most common) transmembrane dimerization motif in biology.

It is found in a variety of biological structures and its dimerization interface is mediated by GxxxG or similar sequence patterns.

Why is it called GASright?

GASright takes its name from the Gly, Ser and Ala amino acids (GAS) at its interaction interface. These small amino acids form GxxxG and similar (GxxxA, SxxxG, etc.) sequence patterns. The "right" refers to the right-handed crossing angle.